gdca mce Search Results


cobimetinib  (MedChemExpress)
93
MedChemExpress cobimetinib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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vivo reporter assay vismodegib  (MedChemExpress)
95
MedChemExpress vivo reporter assay vismodegib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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akt inhibitor ipatasertib  (MedChemExpress)
95
MedChemExpress akt inhibitor ipatasertib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Akt Inhibitor Ipatasertib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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taselisib  (MedChemExpress)
93
MedChemExpress taselisib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Taselisib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gdc 0994  (MedChemExpress)
95
MedChemExpress gdc 0994
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Gdc 0994, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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venetoclax  (MedChemExpress)
96
MedChemExpress venetoclax
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Venetoclax, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pictilisib  (MedChemExpress)
93
MedChemExpress pictilisib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Pictilisib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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70mmol l 1 paxalisib  (MedChemExpress)
93
MedChemExpress 70mmol l 1 paxalisib
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
70mmol L 1 Paxalisib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gdc0623  (MedChemExpress)
93
MedChemExpress gdc0623
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Gdc0623, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gdc 0152  (MedChemExpress)
94
MedChemExpress gdc 0152
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Gdc 0152, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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erk1 2 inhibitor ravoxertinib hydrochloride  (MedChemExpress)
93
MedChemExpress erk1 2 inhibitor ravoxertinib hydrochloride
Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ <t>Cobimetinib,</t> 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Erk1 2 Inhibitor Ravoxertinib Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ Cobimetinib, 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Journal: Bioactive Materials

Article Title: Modeling human hypertrophic scars with 3D preformed cellular aggregates bioprinting

doi: 10.1016/j.bioactmat.2021.09.004

Figure Lengend Snippet: Performance of predicted drugs in the bioprinted scar model. (A) The enrichment of gene sets from the GO database. (B) Schematic illustration of mechanism of drug screen. (C, D) The expression of pro-fibrotic molecule and anti-fibrotic molecule at gene (C) (Data are mean ± SEM, n = 3, * p < 0.05) and protein (D) level (α-SMA, TGFβ1, TGFβ3: green, DAPI: blue, scale bar = 25 μm). 3ASS: 3A5G+SFb+scar ECM, 3A–D: 3ASS+DMSO, 3A–A: 3ASS+ Abemaciclib, 3A–C: 3ASS+ Cobimetinib, 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: 3D-bioprinted scar model was treated with Abemaciclib (CDK4/6 inhibitor, MCE), Cobimetinib (MEK1/2 inhibitor, MCE) and Triamcinolone acetonide (glucocorticoid for clinical application, KUNMIN JIDA).

Techniques: Expressing

Transplantation of scar model into adult immunodeficient mice displays characteristics of early stage of scar and confirmed the effect of screened drugs. (A) Schematic illustration of the whole process of animal test. (B) The macroscophic images of scar formation in different groups. (C) HE (Scale bar = 200 μm) and Masson images (Scale bar = 200 μm) of scar tissue in different groups. (D) The expression of myofibroblasts markers in different groups (α-SMA, Col I: red, DAPI: blue, scale bar = 100 μm). 3A5G: 3A5G+SFb+scar ECM, 3A–C: 3ASS+ Cobimetinib, 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Journal: Bioactive Materials

Article Title: Modeling human hypertrophic scars with 3D preformed cellular aggregates bioprinting

doi: 10.1016/j.bioactmat.2021.09.004

Figure Lengend Snippet: Transplantation of scar model into adult immunodeficient mice displays characteristics of early stage of scar and confirmed the effect of screened drugs. (A) Schematic illustration of the whole process of animal test. (B) The macroscophic images of scar formation in different groups. (C) HE (Scale bar = 200 μm) and Masson images (Scale bar = 200 μm) of scar tissue in different groups. (D) The expression of myofibroblasts markers in different groups (α-SMA, Col I: red, DAPI: blue, scale bar = 100 μm). 3A5G: 3A5G+SFb+scar ECM, 3A–C: 3ASS+ Cobimetinib, 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: 3D-bioprinted scar model was treated with Abemaciclib (CDK4/6 inhibitor, MCE), Cobimetinib (MEK1/2 inhibitor, MCE) and Triamcinolone acetonide (glucocorticoid for clinical application, KUNMIN JIDA).

Techniques: Transplantation Assay, Expressing